Development Activities at Shionogi Inc.

Compound

Phase I

Phase II

Phase III

Filing

Approved

hs hs hs hs hs hs hs hs hs hs hs hs hs hs hs
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Compound

S-707106

Mechanism:

Insulin sensitizer

Therapeutic area:

Type 2 Diabetes

Development phase:

Phase 2

Origin:

Shionogi Discovered

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Compound

S-234462

Mechanism:

NPY Y5 receptor antagonist

Therapeutic area:

Obesity

Development phase:

Phase 1

Origin:

Shionogi Discovered

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Compound

S-349572/S-265744/S-247303*

Mechanism:

Integrase inhibitor

Therapeutic area:

HIV infection

Development phase:

Phase 3

Origin:

Joint Venture

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Compound

S-265744 LAP injection*

Mechanism:

Integrase inhibitor

Therapeutic area:

HIV infection

Development phase:

Phase 1

Origin:

Joint Venture

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Compound

S-297995

Mechanism:

Peripheral receptor agonist

Therapeutic area:

Alleviation of opioid-induced adverse effects

Development phase:

Phase 2

Origin:

Shionogi discovered

Clinical trial information: click here

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Compound

Ospemifene

Mechanism:

Selective estrogen receptor modulator

Therapeutic area:

PM Vaginal atrophy

Development phase:

Phase 3

Origin:

In-licensed

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Compound

PSD502 (lidocaine/prilocaine)

Mechanism:

Topical anesthetics

Therapeutic area:

Premature ejaculation

Development phase:

Phase 3

Origin:

In-licensed

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Compound

S-888711

Mechanism:

Thrombopoietin receptor agonist

Therapeutic area:

Thrombocytopenia

Development phase:

Phase 2

Origin:

Shionogi discovered

Clinical trial information: click here,

Compounds marked by * are being developed through Shionogi-ViiV Healthcare LLC. is a joint venture that Shionogi Inc. supports.

This pipeline presentation contains general information about Shionogi's products in development. The development activities include many aspects which we have not attempted to capture in this high-level overview. Investors should be aware that many factors, some of which are beyond the control of the company, can impact the feasibility and commercial value of each development project, and the portfolio as a whole.

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Compound

S-555739

Mechanism:

PGD2 receptor antagonist

Therapeutic area:

Allergic rhinitis

Development phase:

Phase 1

Origin:

Shionogi discovered



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